Cardiovascular calcifications are frequent in the general population during aging but also in patients with CKD. They are associated with an increased risk of cardiovascular morbi-mortality. Vascular calcifications result from a calcium deposition localized essentially in the media of the vascular wall, and are often associated with calcified intimal atheroma plaques. However, the molecular mechanisms involved in these processes and the consequences of cardiovascular calcifications are not yet clearly elucidated. For more than 4 years, our research unit has worked to elucidate the mechanisms and the consequences of cardiovascular calcifications and to identify strategies to prevent or treat vascular calcifications. Since chronic kidney disease (CKD) increases the incidence of cardiovascular calcifications, an important part of our experimental and clinical researches was developed in the context of CKD.